Immunohistochemically: Immunohistochemical investigation was performed. The following molecular markers were used: oncoprotein p53, Bcl-2, Ki-67, CD20 and catepsin D (visualization system - LSAB, substrate – DAB). As a result of immunohistochemical investigation it was revealed, that in area of papillary structures 1) oncoprotein p53 is negative; 2) Bcl-2 – negative; 3) Ki-67 – negative; 4) Catepsin D – is moderately positive; 5) CD20 is positive in lymphoid follicles.

Histopathologic diagnosis: Encapsulated variant of thyroid gland papillary carcinoma associated with Hashimoto’s thyroiditis, negativity of oncoptotein p53 and Ki-67 and moderate positive test of catepsin D.

P.S. Negativity of oncoprotein p53 and moderate positive test of catepsin D indicate upon the low metastatic potential.

Comments:  Please, write Your opinion and the suggestions about the further treatment strategy of this case to Eka Kldiashvili, Ph.D. kldiashvili@georgia.telepathology.org, Georgian Telemedicine Union (Association), Tbilisi, Georgia.